This study presents the first application of a high-resolution magic angle spinning 1H NMR approach to elucidate the metabolic effects of a hypercholesterolemic condition and two high-fiber diets based on rye and wheat bread, respectively, in intact pig liver biopsy samples. Standard 1D and spin−echo 1H spectra were acquired on a total of 20 biopsy samples, and 2D total correlation spectroscopy experiments were carried out on selected samples for assignment of the observed resonances. Principal component analyses and partial least-squares regression discriminant analysis revealed differences in the hepatic lipid content and choline-containing compounds between normal and hypercholesterolemic pigs. In addition, the results demonstrated that the liver metabolite profile of hypercholesterolemic pigs fed a high-fiber rye bread differed from that of pigs fed high-fiber wheat bread with respect to both the lipoprotein fractions and the choline-containing compounds. These findings suggest that earlier reports on high-fiber rye diet-induced effects on plasma HDL/LDL content partially can be ascribed to effects on liver cholesterol metabolism and that the hepatic phospholipase pathways of phosphatidylcholine breakdown are affected by the high-fiber rye diet.
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英文翻译
本研究提出应用旋转角度高清晰的魔法的方法来阐明核磁共振的代谢作用hypercholesterolemic条件的基础上,两个高纤维食物、全麦面包、分别黑麦、完整的猪肝活检标本。标准的一维氢谱和旋转−得到回音共20活检标本、二维总相关光谱进行了试验研究,在选定的样品所观察到的谐振的任务。主成分分析和偏最小二乘回归法判别分析显示肝脂含量差异总肌酐和胆碱成分hypercholesterolemic正常、猪。此外,研究结果表明肝脏代谢的hypercholesterolemic猪喂食高纤黑麦面包不同,猪喂食高纤全麦面包就双方的choline-containing馏份的低密度脂蛋白的化合物。这些研究表明,早期的报告对高纤黑麦diet-induced血浆高密度脂蛋白(HDL)/低密度脂蛋白(LDL)影响内容部分可以归结于肝脏胆固醇代谢的影响,phosphatidylcholine通道的肝脏碱性击穿受高纤黑麦的饮食。
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